Publications
Recent highlights
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer.
Contributions from Jo, Kitty and Stuart.
Selected publications
Hamdan A and Ewing A. ‘Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis’. (2022) The Journal of Pathology, https://doi.org/10.1002/path.5901.
Gershenson D, Miller A, Brady WE, …, Ewing A,…, Gourley C. ‘Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial’. (2022) The Lancet. (399) (10324) 541-553.
Ewing A, Meynert A, Churchman M et al. ‘Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma’ (2021) Clinical Cancer Research (27) (11) 3201-3214.
Aitken SJ, Anderson CJ, Connor F, …,Ewing A,…, Taylor M. ‘Pervasive lesion segregation shapes cancer genome evolution’ (2020) Nature 583 (7815), 265-270.
Travnickova J, Wojciechowska S, Khamseh A,…Ewing A…Patton E. ‘Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease’ (2019). Cancer research. 79 (22), 5769-5784.
Ewing A, Semple C. ‘Breaking point: the genesis and impact of structural variation in tumours’ (2018) F1000Research 7.
Phelan CM, Kuchenbaecker KB, JP Tyrer,… Pirie A … Pharoah PDP. ‘Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer’ (2017) Nature genetics 49 (5), 680-691.
Permuth JB*, Pirie A*, Chen A et al. ‘Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.’ (2016) Human Molecular Genetics 25 (16), 3600-3612. (* - equal contributions).
Winham S*, Pirie A*, Chen A et al. ‘Investigation of exomic variants associated with overall survival in ovarian cancer’ (2016) Cancer Epidemiology Biomarkers and Prevention. Mar;25(3):446-54. (* - equal contributions)
Pirie A, Guo Q, Kraft P et al. ‘Common germline polymorphisms associated with breast cancer specific survival’ (2015) Breast Cancer Research. 17:58.
Pirie A, Wood A, Lush M et al. ‘The effect of rare variants on inflation of the test statistics in case-control analyses’ (2015) BMC Bioinformatics 16:53.
Full list of publications on Google Scholar